Best CBD Oil for Anxiety & Depression

Best CBD Oil for Anxiety & Depression
This article was vetted for scientific accuracy by a PhD researcher.

Finding the best CBD oils for anxiety, or the best CBD oils for depression, can take a lot of time, money, and hard work. And if you’re like most people, you don’t want to waste your resources going through hundreds of products.

In this guide, you’ll learn all about the most reputable CBD brands on the market today and everything you need to know about using CBD oil for anxiety or depression.

We’ve spent hours narrowing down this list so you wouldn’t have to spend hours researching and reading online reviews, comparing prices or trying out all possible CBD products – we’ve done the work so that you don’t have to. 

Check out our top recommendations below:

Spruce CBD Oil
Best Full Spectrum

Spruce CBD Oil

Sabaidee CBD Oil
best price

Sabaidee CBD Oil

RoyalCBD CBD Oil
Most Potent

RoyalCBD CBD Oil

CBDPure Hemp Oil
highest quality

CBDPure Hemp Oil

NuLeaf Naturals CBD Oil
Best Organic

NuLeaf Naturals CBD Oil

1. Spruce CBD Oil – Best Full Spectrum & Top Pick

Spruce CBD Oil – Best Full Spectrum & Top Pick

Our Rating

Customer Service100%
Transparency & Accuracy100%


Get 10% off Spruce CBD oil as an AmericanMarijuana reader. Use this code at checkout: AMMA

Get Discount

Spruce CBD is one of the strongest CBD oils you can get for the best value. Despite being a fairly new player in the market, Spruce CBD is able to keep up with the competition and industry demand thanks to the quality of their CBD products.

The company gets their industrial hemp from farms in Kentucky and Colorado. The plants are grown and farmed without the use of pesticides, creating a safer end product.

As for concentration, the brand only offers two. Take note that compared with a lot of other CBD oils, Spruce CBD oils have a higher potency, ranging from 750 to 2400mg per bottle.

Each ml of the oil has about 80mg of CBD.

Another nice thing about the brand is that it lets you pick what carrier oil you want for your product. You can choose between organic hemp seed oil and organic MCT oil.

2. Sabaidee CBD Oil – Best Price

Sabaidee CBD Oil – Best Price

Our Rating

Customer Service100%
Transparency & Accuracy100%


Get 15% off all Sabaidee CBD products as an AmericanMarijuana reader. Use this code at checkout: AmericanMarijuana

Get Discount

Sabaidee CBD oil is one of the best CBD oils on the market today. It comes from 100% organically grown hemp. Each bottle undergoes independent third-party lab testing to give you peace of mind when it comes to quality, purity, and effectiveness.

Now, let’s talk about the variants and potency. There are three options for you to choose from. 

The Good Vibes 250mg+ is a good choice for new or long-term users of CBD products. It’s an all-natural, full-spectrum CBD hemp extract mixed with peppermint oil for flavor and MCT oil as its carrier.

Because it’s a full-spectrum CBD oil, you get a full range of cannabinoids and terpenes from it. Many people believe that the combination of all those components makes the oil more effective.

Apart from the Good Vibes, Sabaidee also has the Super Good Vibes that pack about 33.5mg of CBD per dropper. 

Then, there’s the Mega Good Vibes that offers 88.33mg of CBD per serving. This is one of the highest concentrations of CBD we found in any oil, perfect for heavy users.

Now, despite the high potency, the product still has the legally allowed level of THC. It won’t alter your focus or cause any unwanted intoxicating effects.

3. Royal CBD – Most Potent

Royal CBD – Most Potent

Our Rating

Customer Service98%
Transparency & Accuracy99%

Get 10% off all Royal CBD products as an AmericanMarijuana reader. Use this code at checkout: AmericanMarijuana

Get Discount

Royal CBD Oil offers great value for your money. Considering its concentration per bottle, amount, and the brand that created it, it’s surely worth every penny.

The oil is extracted using CO2.

After using pressurized carbon dioxide to extract the CBD oil, it’s compressed and processed into a supercritical cold liquid state. 

Another thing to note about these oils is that they are submitted to strict laboratory testing to ensure that they are safe to consume. If any product fails to pass, it’s disposed of right away.

4. CBDPure – Highest Quality

CBDPure – Highest Quality

Our Rating

Customer Service100%
Transparency & Accuracy100%


Get 10% off all Pure CBD products as an AmericanMarijuana reader. Use this code at checkout: AMMA

Get Discount

CBDPure is well-known for producing high quality CBD products, so it’s not really surprising that their CBDPure Hemp Oil earned a spot on this list. 

 As mentioned in our review, CBDPure uses only full spectrum CBD which means that you’ll get additional cannabinoids to create that entourage effect. 

The oil comes in three different strengths. The lowest is the 100mg Pure Hemp Oil bottle which provides about 3.3mg of CBD per serving.

If that dose isn’t enough for you, there’s the option for you to go for the highest dosage bottle, which is the 600mg Pure Hemp Oil. It provides about 20mg of CBD oil per serving.

5. NuLeaf Naturals CBD Oil – Best Organic

NuLeaf Naturals CBD Oil – Best Organic

Our Rating

Customer Service99%
Transparency & Accuracy100%


NuLeaf CBD oil has a slightly bitter and nutty taste. It’s because NuLeaf doesn’t use additives in its CBD oils.

If you are new to taking CBD oil, you might need some time to get used to the taste. In case you are really having a hard time taking it as it is, you have the option to add it to your drinks or food.

NuLeaf Naturals only uses organic hemp for all of its products. They are also tested by a third-party lab to ensure safety and purity.

NuLeaf Naturals strictly comply with federal standards. The oils have no more than 0.3% THC, like all federally legal CBD products.

What Is Anxiety?


Anxiety is a normal human response to potentially harmful triggers. It initiates the “fight-or-flight” response where the body can experience a rush of adrenaline, increased sensitivity to the environment, sweating, and increased heartbeat.

When the anxious feeling gets out of proportion to the trigger, the anxiety progresses into an anxiety disorder. Once it reaches that stage, the anxiety has become severe enough that it interferes with a person’s daily function and mental health.

The Main Types of Anxiety Disorders

Generalized Anxiety Disorder – This refers to a chronic disorder where people experience excessive and chronic anxiety about non-specific objects and life events. It’s considered to be the most common anxiety disorder.

Specific Phobias – These phobias create an intense fear about a specific situation and/or object. They often cause people to avoid ordinary situations out of fear.

Social Anxiety Disorder – This condition triggers an overwhelming worry about normal daily situations and interactions, particularly those involving other people. It causes a fixation on being embarrassed and judged.

Panic Disorder – This disorder can strike unexpectedly. It causes sudden panic attacks that consist of one– or usually multiple– of the following symptoms: breathing difficulty, confusion, dizziness, shaking, nausea, and intense terror. It can last from minutes to hours.

Symptoms of Anxiety Disorders

While anxiety disorders can refer to different conditions, they share some common symptoms. Below is a quick list of their general symptoms:

  • Heart palpitations
  • Panic and uneasiness
  • Sleep issues
  • Inability to stay still and calm
  • Shortness of breath
  • Rumination
  • Dry mouth
  • Somatic complaints
  • Dizziness
  • Tense muscles
  • Feelings of dread

What Are the Causes of Anxiety?

The causes of anxiety disorders are complicated. Usually, there’s more than just one factor involved.

Causes of anxiety can include:


Having a family member diagnosed with a type of anxiety disorder has the potential to increase one’s risk of developing the same condition.

Environmental factors

There are certain elements in your environment that can make your anxiety worse. This includes the stress you experience at work, at school or even at home. The stress of having financial problems can also contribute to the medical condition. 

Lack of sleep because of worrying can make your anxiety worse as well.

Using CBD Oil for Anxiety

cbd leaves in best cbd oil for anxiety

Managing anxiety is not as simple as it sounds – prescription drugs can be costly, and come with a host of side effects. They can also carry a great risk of addiction. For these reasons and more, some people are turning to CBD oil for anxiety instead of pharmaceuticals.

But the question remains: Can CBD oil truly help treat anxiety?

Preliminary data and anecdotal evidence points to yes:

According to a 2015 review published in Neuropathics, “We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive–compulsive disorder, and post-traumatic stress disorder when administered acutely.” They go on to say that “CBD exhibits a broad range of actions, relevant to multiple symptom domains, including anxiolytic, panicolytic, and anticompulsive actions, as well as a decrease in autonomic arousal, a decrease in conditioned fear expression, enhancement of fear extinction, reconsolidation blockade, and prevention of the long-term anxiogenic effects of stress.” In layman’s terms, this study indicates that CBD has potential to reduce anxiety and compulsive behavior, and to reduce the long-term anxiety-inducing effects of stress.

And the best part?

CBD is not known to cause many of the side effects of pharmaceutical medications, and it’s non-habit-forming. That’s what we call a win-win.

How do you choose the best CBD oil for anxiety?

CBD oil is not regulated by the FDA in the United States, unlike your traditional anxiolytics. 

This is why you should really know your options and be thorough in reading reviews and scientific information. Check if the CBD oil you plan to purchase is safe, pure, and of high-quality.

There are a couple of criteria you can use to check the quality of your CBD oil for anxiety. Below is a quick overview:

How the CBD oil is made

Choosing a company is critical in determining your CBD oil’s quality. You see, brands have different extraction methods and ways of processing CBD or cannabidiol oil.

With that, you may want to research the brand’s production method. Find out how their CBD oils are extracted. As much as possible, stick with brands that use CO2 extraction, as many consider it to be the best and safest way to extract CBD oil.

The source

The cannabis plant has this ability to absorb anything that’s within its environment. So if you use an oil that has been extracted from a hemp plant grown in contaminated soil, the result will be unsatisfactory, too.

Third-party lab testing

Reputable CBD oil brands and companies should have third-party lab results ready and accessible to its consumers. These lab reports should test not only for cannabinoid content, but impurities as well – things like heavy metals, pesticides, solvents, mycotoxins and more. You can look for them in the packaging of your oil or the brand’s website.

If you can’t find it online, you can always email them about the results or any evidence of their products getting tested.. If you don’t get a reply, consider looking at other companies.

How to Use CBD Oil for Treating Anxiety

At this point, you’re probably wondering how much to take to ease your medical condition. Well, the answer varies and it’s not enough to rely on the guides you can find online.

If you plan to use CBD oil to treat anxiety or depression, the very first thing you need to do is talk to your doctor or mental health professional. It is not advised to use CBD for depression or anxiety without speaking to a professional first.

People react differently to CBD and how fast the oil works in easing the symptoms of anxiety will depend on the individual. Your height and weight are factors that need to be keep in mind when determining the right dosage. Your existing medical conditions, diet, and medications matter, too.

Can CBD oil help with depression?

Depression is a very common mood disorder, affecting an estimated 6.7% of the adult American population.

To be diagnosed with depression, the DSM outlines the following criteria. Persons must exhibit 5 or more of these symptoms within a 2-week period to be diagnosed with depression:

  1. Depressed mood most of the day, nearly every day.
  2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day.
  3. Significant weight loss when not dieting or weight gain, or decrease or increase in appetite nearly every day.
  4. A slowing down of thought and a reduction of physical movement (observable by others, not merely subjective feelings of restlessness or being slowed down).
  5. Fatigue or loss of energy nearly every day.
  6. Feelings of worthlessness or excessive or inappropriate guilt nearly every day.
  7. Diminished ability to think or concentrate, or indecisiveness, nearly every day.
  8. Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

Depression can be a severe and dangerous condition, and is commonly treated with antidepressant drugs like SSRIs or SNRIs. 

While it shouldn’t be considered as a complete replacement for antidepressants or other treatment plans, research shows that CBD can help alleviate depression symptoms. For example, one review found that “preliminary clinical trials support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant.” Another review noted that, while the mechanisms of action are underresearched, “it is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis.”

While further research is needed, preliminary evidence shows promise for using CBD oil for depression. As always, make sure to consult with your doctor or a medical professional before you start taking CBD for depression.

So, what’s the ideal CBD dose?

The golden rule for CBD dosage is to “start low, and go slow” – meaning to start with the smallest possible dose, and increase gradually week-by-week until the desired effect is achieved. While there’s no real risk of overdosing on CBD, nor are you likely to experience severe side effects, you might make your CBD tolerance skyrocket – that means you’ll need to take more (and spend more) to get the same effect. 

risk of cbd oil

Final thoughts on CBD oil for anxiety and depression

The use of CBD oil in managing anxiety and depression is getting more and more common. 

However, despite the increasing demand for the oil and the suggested benefits of CBD, you should still exercise caution. First things first, always consult with your doctor before taking CBD for anxiety, depression, or for any other condition. Once you’ve got your doctor’s approval, you should try to find high-quality CBD oil and make sure you know how much you should take. Your doctor may even be able to help you determine your dosage.

From all the products we reviewed, the best CBD oil for anxiety is Spruce CBD Oil. Its impressive CBD oils are effective not just in managing anxiety but also in managing diabetes – blood pressure, improving sleep at night, and controlling blood glucose levels.

Now, if the taste of CBD oil bothers you, you can try other CBD products. You can consider CBD gummies, capsules, edibles, vapes, and tons of other formulations.

Just make sure to consider the potency and doses when switching products.

If you are planning to purchase online, make sure to double check everything. Read reviews and do further research not just about the companies but also the retailers.

Understand that with a high demand for cannabidiol oil these days, there’s a good chance you might see a couple of dishonest retailers not just online but in your local market, too. Be careful as the industry is saturated with fake and misleading products that are sold at high prices.

Go to Spruce by clicking the button below and enter coupon code AMMA for 10% OFF

You may want to save even more money while coping with anxiety by shopping in our deals section:

Dwight K. Blake Written by: Dwight K. Blake

Dwight was a Mental Health counselor at Long Island Psychotherapy & Counseling in Westbury, New York for more than 15 years. He believes that CBD is the prime solution to this mental illness and more-- with proper research, medical acknowledgment, and application.
Through his work at AmericanMarijuana, together with the rest of the team, he wishes to provide everyone with genuine results and high-quality product reviews for everyone to enjoy for free.

Leave a Comment