Best CBD Oil for Anxiety & Depression

Best CBD Oil for Anxiety & Depression
This article was vetted for scientific accuracy by a PhD researcher.

Finding the best CBD oils for anxiety, or the best CBD oils for depression, can take a lot of time, money, and hard work. And if you’re like most people, you don’t want to waste your resources going through hundreds of products.

In this guide, you’ll learn all about the most reputable CBD brands on the market today and everything you need to know about using CBD oil for anxiety or depression.

We’ve spent hours narrowing down this list so you wouldn’t have to spend hours researching and reading online reviews, comparing prices or trying out all possible CBD products – we’ve done the work so that you don’t have to. 

Check out our top recommendations below:

Top 5 CBD Oils for Anxiety

CBDfx CBD And CBG Wellness Tincture
Best formula

CBDfx CBD And CBG Wellness Tincture

Sabaidee Good Vibes CBD Oil
most trusted brand

Sabaidee Good Vibes CBD Oil

Fab CBD Oil Drops
best flavors

Fab CBD Oil Drops

RoyalCBD CBD Oil
Most Potent

RoyalCBD CBD Oil

NuLeaf Naturals CBD Oil
high quality

NuLeaf Naturals CBD Oil

CBDistillery CBD Oil
best isolate

CBDistillery CBD Oil

1. CBDfx CBD And CBG Wellness Tincture

CBDfx CBD And CBG Wellness Tincture

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  • Ingredients: Broad-spectrum hemp oil, MCT oil, coconut oil, proprietary terpene blend, coenzyme Q10, curcumin & stevia rebaudiana extract
  • Price: $0.04–$0.07/mg
  • Potency: 17–67mg/ml

The CBDfx CBD + CBG Wellness Tincture 2:1 is our top pick as the best CBD oil for depression and anxiety. The company’s latest CBD oil, the Wellness Tincture, combines two of the most powerful cannabinoids of the hemp plant, cannabidiol (CBD) and cannabigerol (CBG), along with a proprietary blend of 18 aromatic terpenes and some helpful antioxidants like coenzyme Q10 and curcumin.

The citrus-flavored tincture comes in four different CBD potencies: 500mg, 1,000mg, 2,000mg, and 4,000mg, with each bottle having a 2:1 ratio of CBD:CBG.

Despite the 4,000mg bottle being named Maximum Strength Plus, the mg/ml count (67mg/ml) is actually the same as the 2,000mg bottle (Maximum Strength). This is because the Maximum Strength Plus bottle contains 60ml of CBD oil, whereas all the other bottles contain the industry standard of 30ml. However, if you want to take more than 67mg per dose, you can simply consume more than one dropper of oil at a time. The Maximum Strength Plus would be an ideal purchase if you know you will eventually buy more than one bottle of the Maximum Strength as it would work out slightly cheaper.

On top of the great value for money, CBDfx is completely transparent by presenting its lab results on each individual product page.

2. Sabaidee Good Vibes CBD Oil

Sabaidee Good Vibes CBD Oil

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  • Ingredients: Hemp extract, MCT oil, peppermint oil
  • Price: $0.19/mg
  • Potency: 8.33 mg/ml 

You’ll never hear “your vibe is off” again – meet the Sabaidee Good Vibes tincture. This broad spectrum tincture is made with very simple ingredients, and is lab tested not once but twice; once in-house in their own lab, then again by a third-party lab to ensure objectivity and accuracy. That’s a perfect example of the care and attention Sabaidee puts into all their products.

Sabaidee offers discounts when buying multiple bottles, and our exclusive coupon code stacks on top of that – meaning you can get a killer top-shelf tincture for less.

When you’re looking for a CBD oil for anxiety, THC-free is often a great option, since some people are sensitive enough to THC that it could actually increase their anxiety. 

Shop Sabaidee Good Vibes CBD tinctures now – and don’t forget to enter the discount code AmericanMarijuana at checkout to save 20%. 

3. FAB CBD Oil Drops

FAB CBD Oil Drops

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  • Ingredients: Full-spectrum hemp extract & MCT oil
  • Price: $0.13/mg
  • Potency: 80mg/ml

When starting out in 2017, the people of FAB CBD combined 25 years of experience in the health, fitness, pharmaceutical, and supplement industries. Along with its transparency, it is clear that this trustworthy company focusses on quality over quantity with its small product line of just three categories.

Available in natural, citrus, mint, vanilla, or berry flavor, you can purchase these 30ml tinctures in four different CBD strengths: 300mg (10mg/ml), 600mg (20mg/ml), 1,200mg (40mg/ml), or 2,400mg (80mg/ml). These varied potency options can work for all different heights, weights, and tolerances to help combat symptoms of anxiety and depression.

FAB CBD sources organically grown hemp from Colorado and constructs its CBD Oil Drops from full-spectrum hemp extract and MCT oil.

If you are not satisfied with your purchase, you have 30 days to return the CBD oil for a full refund. You could also join FAB CBD’s rewards program which allows you to earn points and save money on future purchases.

4. Royal CBD CBD Oil

Royal CBD CBD Oil

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  • Ingredients: Full-spectrum hemp oil, MCT oil, natural flavoring & terpenes
  • Price: $0.09–$0.20/mg
  • Potency: 8–83mg/ml

Royal CBD’s CBD Oil offers great value for your money. Considering its concentration per bottle, the amount, and the brand that created it, we think it’s worth every penny.

This product uses full-spectrum hemp extract which means you won’t miss out on any of the goodness from the whole hemp plant. After using pressurized CO2 to extract the CBD oil, it’s compressed and processed into a supercritical cold liquid state. 

You can choose from four CBD strengths: 250mg, 500mg, 1,000mg, and 2,500mg. Then once you’ve chosen your potency, you can select a berry, mint, vanilla, or natural flavoring. However, there is no mint flavor option for the 250mg bottle. 

Another thing to note about these oils is that they are submitted to strict laboratory testing to ensure that they are safe to consume. If a product fails any of the tests, it’s disposed of right away.

5. NuLeaf Naturals CBD Oil

NuLeaf Naturals CBD Oil

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  • Ingredients: Full-spectrum hemp extract & organic virgin hemp seed oil
  • Price: $0.07–$0.10/mg
  • Potency: 60mg/ml

NuLeaf Naturals’ CBD tincture comes in a 300mg, 900mg, 1,800mg, 3,000mg, and a 6,000mg bottle, with each of these containers increasing in size to match the increasing CBD count. Despite the varied strengths, the CBD potency is 60mg/ml no matter which bottle you choose.

With over 22,000 product reviews on the website, the overall star rating for this CBD oil is an impressive 4.9 out of 5 and there are some brilliant customer comments.

NuLeaf Naturals uses “advanced subcritical and supercritical CO2 extraction to obtain a complete range of cannabinoids, terpenes, essential oils, and other beneficial phytonutrients.”

The company offers a subscription service which allows regular customers to save 10% on products. On top of that, it provides free shipping within the whole of the U.S. The only downside is that you are only eligible for a refund on your purchase if it is returned completely unused and unopened. Even then, you have to pay for your own postage.

6. CBDistillery CBD Oil

CBDistillery CBD Oil

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  • Ingredients: CBD isolate & MCT oil
  • Price: $0.06/mg
  • Potency: 17mg/ml

Seeing as CBD is the cannabinoid in all the studies that has been shown to alleviate symptoms of anxiety and depression, perhaps you want to try a CBD product without all the other elements of the hemp plant. If that’s the case, CBDistillery’s pure CBD oil could be what you’re after.

Extracted from American non-GMO hemp, this pure CBD isolate tincture is great value for money — plus it regularly goes on sale, so keep your eyes peeled! Despite its many other offerings, the tinctures are the most popular product from CBDistillery, one of the most reliable brands in today’s CBD market.

Aside from the pure CBD isolate tincture, the company also offers a broad-spectrum version, with both options coming in 500mg, 1,000mg, and 2,000mg of CBD.

What Is Anxiety?


Anxiety is a normal human response to potentially harmful triggers. It initiates the fight-or-flight response during which the body can experience a rush of adrenaline, increased sensitivity to the environment, sweating, and a faster heartbeat.

When the anxious feeling is out of proportion with the trigger, it progresses into an anxiety disorder. Once it reaches that stage, the anxiety has become severe enough that it interferes with a person’s daily function and mental health.

The Main Types of Anxiety Disorders

Generalized Anxiety Disorder – This is the most common anxiety disorder and refers to when people experience excessive and chronic anxiety about non-specific objects and life events. 

Specific Phobia – Phobias create an intense, irrational fear about a specific situation or object. They often cause people to avoid ordinary situations out of fear.

Social Anxiety Disorder – This condition triggers an overwhelming worry about normal daily situations and interactions, particularly those involving other people. It causes a fixation on being embarrassed and judged.

Panic Disorder – This disorder can strike unexpectedly. It causes sudden panic attacks that consist of one — or usually multiple — of the following symptoms: breathing difficulty, confusion, dizziness, shaking, nausea, and intense terror. Symptoms can last from minutes to hours.

Symptoms of Anxiety Disorders

While anxiety disorders can refer to different conditions, they share some common symptoms. Below is a quick list of their general symptoms:

  • Heart palpitations
  • Panic and uneasiness
  • Sleep issues
  • Inability to stay still and calm
  • Shortness of breath
  • Rumination
  • Dry mouth
  • Somatic complaints
  • Dizziness
  • Tense muscles
  • Feelings of dread

What Are the Causes of Anxiety?

The causes of anxiety disorders are complicated. Usually, there’s more than just one factor involved.

Causes of anxiety can include:


Having a family member diagnosed with a type of anxiety disorder has the potential to increase one’s risk of developing the same condition.

Environmental factors

There are certain elements in your environment that can make your anxiety worse. This includes the stress you experience at work, at school or even at home. The stress of having financial problems can also contribute to the medical condition. 

Lack of sleep because of worrying can make your anxiety worse as well.

Using CBD Oil for Anxiety

cbd leaves in best cbd oil for anxiety

Managing anxiety is not as simple as it sounds – prescription drugs can be costly, and come with a host of side effects. They can also carry a great risk of addiction. For these reasons and more, some people are turning to CBD oil for anxiety instead of pharmaceuticals.

But the question remains: Can CBD oil truly help treat anxiety?

Preliminary data and anecdotal evidence points to yes:

According to a 2015 review published in Neuropathics, “We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive–compulsive disorder, and post-traumatic stress disorder when administered acutely.” They go on to say that “CBD exhibits a broad range of actions, relevant to multiple symptom domains, including anxiolytic, panicolytic, and anticompulsive actions, as well as a decrease in autonomic arousal, a decrease in conditioned fear expression, enhancement of fear extinction, reconsolidation blockade, and prevention of the long-term anxiogenic effects of stress.” In layman’s terms, this study indicates that CBD has potential to reduce anxiety and compulsive behavior, and to reduce the long-term anxiety-inducing effects of stress.

And the best part?

CBD is not known to cause many of the side effects of pharmaceutical medications, and it’s non-habit-forming. That’s what we call a win-win.

How do you choose the best CBD oil for anxiety?

CBD oil is not regulated by the FDA in the United States, unlike your traditional anxiolytics. 

This is why you should really know your options and be thorough in reading reviews and scientific information. Check if the CBD oil you plan to purchase is safe, pure, and of high-quality.

There are a couple of criteria you can use to check the quality of your CBD oil for anxiety. Below is a quick overview:

How the CBD oil is made

Choosing a company is critical in determining your CBD oil’s quality. You see, brands have different extraction methods and ways of processing CBD or cannabidiol oil.

With that, you may want to research the brand’s production method. Find out how their CBD oils are extracted. As much as possible, stick with brands that use CO2 extraction, as many consider it to be the best and safest way to extract CBD oil.

The source

The cannabis plant has this ability to absorb anything that’s within its environment. So if you use an oil that has been extracted from a hemp plant grown in contaminated soil, the result will be unsatisfactory, too.

Third-party lab testing

Reputable CBD oil brands and companies should have third-party lab results ready and accessible to its consumers. These lab reports should test not only for cannabinoid content, but impurities as well – things like heavy metals, pesticides, solvents, mycotoxins and more. You can look for them in the packaging of your oil or the brand’s website.

If you can’t find it online, you can always email them about the results or any evidence of their products getting tested.. If you don’t get a reply, consider looking at other companies.

How to Use CBD Oil for Treating Anxiety

At this point, you’re probably wondering how much to take to ease your medical condition. Well, the answer varies and it’s not enough to rely on the guides you can find online.

If you plan to use CBD oil to treat anxiety or depression, the very first thing you need to do is talk to your doctor or mental health professional. It is not advised to use CBD for depression or anxiety without speaking to a professional first.

People react differently to CBD and how fast the oil works in easing the symptoms of anxiety will depend on the individual. Your height and weight are factors that need to be keep in mind when determining the right dosage. Your existing medical conditions, diet, and medications matter, too.

Can CBD oil help with depression?

Depression is a very common mood disorder, affecting an estimated 6.7% of the adult American population.

To be diagnosed with depression, the DSM outlines the following criteria. Persons must exhibit 5 or more of these symptoms within a 2-week period to be diagnosed with depression:

  1. Depressed mood most of the day, nearly every day.
  2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day.
  3. Significant weight loss when not dieting or weight gain, or decrease or increase in appetite nearly every day.
  4. A slowing down of thought and a reduction of physical movement (observable by others, not merely subjective feelings of restlessness or being slowed down).
  5. Fatigue or loss of energy nearly every day.
  6. Feelings of worthlessness or excessive or inappropriate guilt nearly every day.
  7. Diminished ability to think or concentrate, or indecisiveness, nearly every day.
  8. Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

Depression can be a severe and dangerous condition, and is commonly treated with antidepressant drugs like SSRIs or SNRIs. 

While it shouldn’t be considered as a complete replacement for antidepressants or other treatment plans, research shows that CBD can help alleviate depression symptoms. For example, one review found that “preliminary clinical trials support the efficacy of CBD as an anxiolytic, antipsychotic, and antidepressant.” Another review noted that, while the mechanisms of action are underresearched, “it is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis.”

While further research is needed, preliminary evidence shows promise for using CBD oil for depression. As always, make sure to consult with your doctor or a medical professional before you start taking CBD for depression.

So, what’s the ideal CBD dose?

The golden rule for CBD dosage is to “start low, and go slow” – meaning to start with the smallest possible dose, and increase gradually week-by-week until the desired effect is achieved. While there’s no real risk of overdosing on CBD, nor are you likely to experience severe side effects, you might make your CBD tolerance skyrocket – that means you’ll need to take more (and spend more) to get the same effect. 

risk of cbd oil

Final thoughts on CBD oil for anxiety and depression

The use of CBD oil in managing anxiety and depression is getting more and more common. 

However, despite the increasing demand for the oil and the suggested benefits of CBD, you should still exercise caution. First things first, always consult with your doctor before taking CBD for anxiety, depression, or for any other condition. Once you’ve got your doctor’s approval, you should try to find high-quality CBD oil and make sure you know how much you should take. Your doctor may even be able to help you determine your dosage.

From all the products we reviewed, the best CBD oil for anxiety is the CBDfx CBD:CBG tincture. Their proprietary formula of CBD and CBG is optimized to promote calm and may help relieve anxiety.

Now, if the taste of CBD oil bothers you, you can try other CBD products. You can consider CBD gummies, capsules, edibles, vapes, and tons of other formulations.

Just make sure to consider the potency and doses when switching products.

If you are planning to purchase online, make sure to double check everything. Read reviews and do further research not just about the companies but also the retailers.

Understand that with a high demand for cannabidiol oil these days, there’s a good chance you might see a couple of dishonest retailers not just online but in your local market, too. Be careful as the industry is saturated with fake and misleading products that are sold at high prices.

Shop CBDfx Wellness Tincture, our top pick for CBD for Anxiety:

You may want to save even more money while coping with anxiety by shopping in our deals section:

Andrew Cross Written by: Andrew Cross

Editor of AmericanMarijuana. Andrew Cross is a writer, editor, and cannabis expert based in Montreal, Canada. With years of experience in the cannabis and CBD industries, his writing has appeared in a number of blogs and publications, and he has given keynote addresses across several continents. He is also an award-winning creative fiction author.

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