Best CBD Oil for Pain Relief: Top 10 Brands of 2025

CBD oils have gained popularity as a potential remedy for various types of pain, including conditions like fibromyalgia and neuropathic pain. Research suggests that CBD may help alleviate pain through several mechanisms:

Anti-inflammatory Effects – CBD has been shown to reduce inflammation, which is often a key contributor to pain in conditions like multiple sclerosis.

Neuropathic Pain Relief – CBD may be effective in treating neuropathic pain, which results from nerve damage. According to a review in The Lancet, CBD has shown potential in managing chronic osteoarthritis pain when used alongside medications.

Improved Sleep and Mood – Chronic pain often disrupts sleep and negatively impacts mood. CBD’s ability to promote relaxation and reduce anxiety may lead to better sleep quality and improved mood, indirectly contributing to pain relief.

While these findings are promising, it’s important to note that the effectiveness of CBD oil for pain relief can vary among individuals. More research is needed to fully understand its potential benefits and optimal usage.

As with any supplement, it’s advisable to consult with a healthcare professional before starting CBD oil to ensure it’s appropriate for your specific condition and circumstances.

We tried FAB’s CBD oil, and it quickly became one of our favorites. The drops come in four potencies and five flavors, so it was easy to find an option that fit our routine. The oil is made from organic hemp grown in Colorado and blended with fractionated coconut oil, sunflower seed oil, and natural flavors.

When we used it, we noticed it supported daily stress relief, helped with post-workout recovery, and gave us a calm, focused feeling. We also appreciate that it’s non-GMO, pesticide-free, and organically grown. For anyone who values clean ingredients and eco-friendly practices, this CBD oil is a smart choice.

We tested Spruce’s 2400mg Lab-Grade CBD Oil and were impressed by its strength. This formula is one of the most potent options we’ve tried, making it a great pick if you need extra support for joint pain or recovery.

What stood out to us is the choice of carrier oil; you can go with organic hemp seed oil or organic MCT coconut oil. Both blended well, and the oil felt clean and effective. We also like that it’s certified vegan, gluten-free, and made with 100% natural ingredients.

Because it’s full-spectrum and grown in the USA, we experienced the benefits of the entourage effect, which added to its overall impact. If you’re looking for an extra-strength option, this is the best full-spectrum CBD oil for pain.

If you’re looking for a high-quality, full-spectrum experience, look no further than FIVE CBD. Unlike other brands, FIVE CBD oil offers a dose of tetrahydrocannabinol (THC) per dose. These are as follows:

• 1500mg – 50mg CBD / 2mg THC per serving
• 3000mg – 100mg CBD / 2mg THC per serving
• 6000mg – 100mg CBD / 2mg THC per serving

We tested both flavors (Citrus and Mint Chocolate) and found them smooth and easy to take. The oil is made with full-spectrum hemp extract, MCT coconut oil, and natural flavoring, giving us a complete plant profile and the entourage effect.

While the one-time purchase price is higher than some other brands, we appreciate that FIVE offers ways to save, including discount codes and 30% off with a subscription. For anyone who wants a strong, full-spectrum CBD oil, this is a great option.

We tried FOCL’s CBD Oil Drops and found them especially effective for pain relief. They’re available in 1000mg (33mg per serving) 2000mg (67mg per serving), and 3000mg (100mg per serving). For chronic pain, we found the higher strengths worked best.

What stood out most to us is that these drops are made with broad-spectrum CBD extract, so they’re completely THC-free. That gave us peace of mind while letting us experience the benefits of cannabinoids working together.

We also enjoyed the flavor options (Mint, Natural, Orange Cream, Cherry, and Strawberry Lemonade). Each one made the drops easy to add to our morning routine.

We tested the RESTORE CBD and CBG Tincture from The Raw Botanics Co. and found it very different from most CBD oils. Instead of making us feel drowsy, it gave us a gentle energy boost, which made it easier to stay active while managing pain. That makes it a great option if you prefer to stretch, move, or recover actively.

The tincture combines hemp extract with a mix of natural terpenes, plus adaptogens like Ashwagandha, Cordyceps, Turkey Tail, and Turmeric. We noticed this blend worked well for post-workout recovery, helping with soreness and fatigue.

For anyone interested in CBD oil that supports both pain relief and energy, this tincture offers a unique balance we haven’t found in many other products.

We tried Absolute Nature’s 1000mg CBD Tincture and appreciated both its quality and its commitment to sustainability.

The oil is full-spectrum, made with organic hemp extract and blended with MCT oil from coconuts. The MCT oil gave the tincture a smooth texture and also helped our bodies absorb CBD more effectively.

We also review the third-party lab results, which confirmed purity, safety, and potency. For those who want an organic, eco-conscious CBD oil, this tincture is a reliable option.

We tried the CBD + CBG Oil from CBDfx, and it stood out right away. The 2:1 ratio of CBD to CBG gave us strong support for pain and inflammation, without any psychoactive effects.

This oil also includes curcumin, the active compound found in turmeric that has long been used for inflammation. When we tested, we found it especially helpful for easing discomfort from ongoing aches, and we can see why it’s recommended for conditions like arthritis.

CBDfx has a strong reputation in the CBD industry, and this product lived up to the hype. If you’re looking for the best CBD oil for joint pain, this tincture is a solid option.

We tested CBDistillery’s CBD Oil and liked how simple and effective it is. Each 1000mg bottle delivers 33mg of full-spectrum CBD per dropper, giving us a solid daily dose. The oil is made using CO2 extraction, which we know is one of the cleanest and most effective ways to produce CBD.

What we appreciated most was the transparency. CBDistillery provides third-party lab reports for every product, so we were able to check potency and purity ourselves.

The formula is straightforward: CBD extract, MCT oil, and natural terpenes. Nothing unnecessary, just clean oil that works.

When we tried Charlotte’s Web Max Strength CBD Oil, we quickly understood why this brand has such a strong reputation. As one of the pioneers of the CBD industry, they’ve set a high standard for quality.

The oil is made with certified organic full-spectrum hemp extract, which gives us the full range of beneficial compounds (phytocannabinoids, terpenes, flavonoids, and essential fatty acids). Together, these compounds worked well to support pain relief and overall wellness.

We also appreciated the flavor options. While we don’t mind the natural hemp taste, having choices makes it easy to enjoy each dose. For us, this oil delivered both effectiveness and quality in every drop.

Neurogan’s High Potency CBD Oil is definitely made for experienced users. Each half dropper gave us 100mg of CBD, and the clearly marked dropper made dosing simple, even at such a high strength.

What impressed us most was the value. For anyone who needs a stronger daily dose, this oil delivers a lot of CBD without sacrificing quality. Neurogan makes their oils in small batches at a cGMP- and Kosher-certified facility, so we felt confident about the standards behind the product.

We also liked the brand’s eco-friendly practices. They use recycled packaging and avoid artificial dyes, which adds to our trust in the product. For us, this oil was both powerful and responsibly made.

Due to its high potency, this may be the best CBD oil for nerve pain and other hard-to-address conditions.

When choosing the best CBD oil for pain, focus on three main factors:

Your dosage of CBD depends on several internal and external factors:

Internal factors include your weight, tolerance to CBD, any medications or substances you’re taking, and the severity of pain.

External factors include the type of CBD product, its bioavailability, quality, and age.

If you’re new to CBD, it’s best to start low and go slow. A common starting dose is 5-10mg per day for a week, then gradually increase as needed to manage pain effectively.

• Check reviews on and off the brand’s website.
• Look for transparent lab testing.
• Responsive customer service is a good sign.
• Avoid deals that seem “too good to be true.”
• Our curated lists highlight trusted, vetted brands to simplify your search.

CBD oil is a popular and effective option for managing pain.

Our top pick, FAB CBD Oil, is available in multiple potencies, full-spectrum, and a variety of flavors, making it a versatile choice for different needs. Still, all brands we recommend are lab tested, reputable, and trusted in the industry.

Whether you prefer topicals or oral oils, these options provide safe, high-quality solutions. Using this guide, you can find the best CBD oil for pain confidently, knowing you are selecting products that are potent, clean, and effective.